While biomimetic adhesive solutions have succeeded to be used in various engineering applications such as climbing robotic, handling systems facilities and mobile sensor platforms, their adaptation to biomedical engineering, such as patches for external use, is still in its early stage due to critical issues that must be resolved before wide usage.

In this study, we show that the integration of different biomimetic adhesive micro-textures of different shapes. As observed in nature, their adhesive efficiency increases on uneven surfaces under diverse environmental conditions. The integrated samples lead to uniform and stable peeling strength, which enables long-term adhesive ability. Our work sheds light on the synergetic effect of various combinations and their effectiveness in achieving optimized adhesion that could be suitable for biomedical applications.